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Alectinib
Also known as: Alectinib · 1256580-46-7 · CH5424802 · CH 5424802
- CAS No.
- 1256580-46-7
- Formula
- C30H34N4O2
- Molar mass
- 482.6 g/mol
- PubChem CID
- 49806720
Health hazard
Summary
Alectinib is an organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydrochloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a nitrile, a member of piperidines, an organic heterotetracyclic compound, a member of morpholines and an aromatic ketone. It is a conjugate base of an alectinib(1+).
Background
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Physical properties
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Hazards
Storage
Keep at room temperature, below 30 °C, out of direct heat.
Store somewhere well-ventilated and away from any ignition source.
Metal drums or tinted glass, tightly sealed.
Strong acids, strong bases and powerful oxidizers.
Personal protective equipment
Nitrile or butyl, at least 0.4 mm thick.
Safety goggles with side shields.
A2 organic-vapor cartridge if the room isn't well ventilated.
Occupational exposure limits (HSE)
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EU harmonised classification (ECHA C&L)
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Transport
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FDA recalls & enforcement
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Compatibilities
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Open comparator with AlectinibPractical safety notes
- Serious health hazard (carcinogen, mutagen, reprotoxic, respiratory sensitizer). Substitute if possible; otherwise closed systems and medical surveillance.
Derived from the GHS classification shown above. These notes are generic guidance and do not replace the manufacturer's SDS or your local risk assessment.
FAQ
Is Alectinib flammable?+
Alectinib (CAS 1256580-46-7) does not carry the GHS02 flame pictogram in our records. Always confirm with the manufacturer's SDS section 9 (flash point) before assuming a product is non-flammable.
What PPE should I wear when handling Alectinib?+
Safety glasses with side shields and nitrile gloves are the baseline. Work inside a fume hood or use a suitable respirator. Check SDS section 8 for material-specific breakthrough times.
How should Alectinib be stored?+
Store Alectinib (CAS 1256580-46-7) in tightly closed original containers, in a cool, dry, well-ventilated area away from incompatible materials.
Is Alectinib dangerous for the environment?+
No specific environmental pictogram (GHS09) is listed in our records for Alectinib, but any chemical waste should be handled through your site's hazardous-waste procedure, not poured down the drain.
Where can I find the official Safety Data Sheet for Alectinib?+
Official, up-to-date SDS documents are published by each manufacturer (Sigma-Aldrich, Merck, Thermo Fisher, VWR, Carl Roth, etc.) and by regulators such as ECHA and NIOSH. This page is an educational summary and does not replace the manufacturer's SDS.
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