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docetaxel
Also known as: docetaxel · 114977-28-5 · Taxotere · Docetaxel anhydrous
- CAS No.
- 114977-28-5
- Formula
- C43H53NO14
- Molar mass
- 807.9 g/mol
- PubChem CID
- 148124
Harmful / Irritant
Health hazard
Summary
Docetaxel anhydrous is a tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group. It has a role as an antineoplastic agent, an antimalarial and a photosensitizing agent. It is a secondary alpha-hydroxy ketone and a tetracyclic diterpenoid. It derives from a hydride of a taxane.
Background
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Physical properties
Sourced from PubChem Experimental Properties. Values may vary between sources and conditions.
Hazards
Storage
Keep at room temperature, below 30 °C, out of direct heat.
Store somewhere well-ventilated and away from any ignition source.
Metal drums or tinted glass, tightly sealed.
Strong acids, strong bases and powerful oxidizers.
Personal protective equipment
Nitrile or butyl, at least 0.4 mm thick.
Safety goggles with side shields.
A2 organic-vapor cartridge if the room isn't well ventilated.
Occupational exposure limits (HSE)
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EU harmonised classification (ECHA C&L)
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Transport
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FDA recalls & enforcement
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Compatibilities
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Open comparator with docetaxelPractical safety notes
- Irritant / harmful. Ventilate the workspace and avoid skin contact.
- Serious health hazard (carcinogen, mutagen, reprotoxic, respiratory sensitizer). Substitute if possible; otherwise closed systems and medical surveillance.
Derived from the GHS classification shown above. These notes are generic guidance and do not replace the manufacturer's SDS or your local risk assessment.
FAQ
Is docetaxel flammable?+
docetaxel (CAS 114977-28-5) does not carry the GHS02 flame pictogram in our records. Always confirm with the manufacturer's SDS section 9 (flash point) before assuming a product is non-flammable.
What PPE should I wear when handling docetaxel?+
Safety glasses with side shields and nitrile gloves are the baseline. Work inside a fume hood or use a suitable respirator. Check SDS section 8 for material-specific breakthrough times.
How should docetaxel be stored?+
Store docetaxel (CAS 114977-28-5) in tightly closed original containers, in a cool, dry, well-ventilated area away from incompatible materials.
Is docetaxel dangerous for the environment?+
No specific environmental pictogram (GHS09) is listed in our records for docetaxel, but any chemical waste should be handled through your site's hazardous-waste procedure, not poured down the drain.
Where can I find the official Safety Data Sheet for docetaxel?+
Official, up-to-date SDS documents are published by each manufacturer (Sigma-Aldrich, Merck, Thermo Fisher, VWR, Carl Roth, etc.) and by regulators such as ECHA and NIOSH. This page is an educational summary and does not replace the manufacturer's SDS.
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