Educational content for trained professionals. Not a Safety Data Sheet, not medical advice. In an emergency, call your local poison control or emergency services immediately. Terms of use.
Isobutyronitrile
Also known as: Isobutyronitrile · 2-METHYLPROPANENITRILE · 78-82-0 · Isopropyl cyanide
- CAS No.
- 78-82-0
- Formula
- C4H7N
- Molar mass
- 69.11 g/mol
- PubChem CID
- 6559
Flammable
Toxic
Harmful / Irritant
Health hazard
Summary
Isobutyronitrile (C4H7N), CAS 78-82-0. Common in labs and industry. Read on for hazards, storage, PPE and mixing rules.
Background
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Hazards
Ignites easily when exposed to a flame or spark.
May be fatal even in small doses.
May cause skin, eye or respiratory irritation.
Serious long-term health effects (CMR, respiratory sensitizer).
Hazard statements
- H225: Highly Flammable liquid and vapor [Danger Flammable liquids]
- H300: Fatal if swallowed [Danger Acute toxicity, oral]
- H301: Toxic if swallowed [Danger Acute toxicity, oral]
- H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
- H331: Toxic if inhaled [Danger Acute toxicity, inhalation]
- H315: Causes skin irritation [Warning Skin corrosion/irritation]
- H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H330
- H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure
- H310: Fatal in contact with skin [Danger Acute toxicity, dermal]
- H316: Causes mild skin irritation [Warning Skin corrosion/irritation]
- H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]
Storage
Keep at room temperature, below 30 °C, out of direct heat.
Store somewhere well-ventilated and away from any ignition source.
Metal drums or tinted glass, tightly sealed.
Strong acids, strong bases and powerful oxidizers.
Personal protective equipment
Nitrile or butyl, at least 0.4 mm thick.
Safety goggles with side shields.
A2 organic-vapor cartridge if the room isn't well ventilated.
Occupational exposure limits (HSE)
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EU harmonised classification (ECHA C&L)
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Transport
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FDA recalls & enforcement
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Compatibilities
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Open comparator with IsobutyronitrilePractical safety notes
- Flammable. Keep away from open flames, hot surfaces and sparks. Ground containers when transferring.
- Acute toxicity. Work under a fume hood, restrict access, keep a specific antidote plan available.
- Irritant / harmful. Ventilate the workspace and avoid skin contact.
- Serious health hazard (carcinogen, mutagen, reprotoxic, respiratory sensitizer). Substitute if possible; otherwise closed systems and medical surveillance.
Derived from the GHS classification shown above. These notes are generic guidance and do not replace the manufacturer's SDS or your local risk assessment.
FAQ
Is Isobutyronitrile flammable?+
Yes. Isobutyronitrile (CAS 78-82-0) carries the GHS02 flame pictogram. Keep it away from ignition sources, use non-sparking tools, and ground metal containers when transferring liquid.
What PPE should I wear when handling Isobutyronitrile?+
Safety glasses with side shields and nitrile gloves are the baseline. Work inside a fume hood or use a suitable respirator. Check SDS section 8 for material-specific breakthrough times.
How should Isobutyronitrile be stored?+
Store Isobutyronitrile (CAS 78-82-0) in tightly closed original containers, in a cool, dry, well-ventilated area away from incompatible materials. Use a flammable-liquid cabinet and keep away from oxidizers and heat.
Is Isobutyronitrile dangerous for the environment?+
No specific environmental pictogram (GHS09) is listed in our records for Isobutyronitrile, but any chemical waste should be handled through your site's hazardous-waste procedure, not poured down the drain.
Where can I find the official Safety Data Sheet for Isobutyronitrile?+
Official, up-to-date SDS documents are published by each manufacturer (Sigma-Aldrich, Merck, Thermo Fisher, VWR, Carl Roth, etc.) and by regulators such as ECHA and NIOSH. This page is an educational summary and does not replace the manufacturer's SDS.
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