Educational content for trained professionals. Not a Safety Data Sheet, not medical advice. In an emergency, call your local poison control or emergency services immediately. Terms of use.
methyl isobutyl ketone
Also known as: 4-Methyl-2-pentanone · METHYL ISOBUTYL KETONE · 4-Methylpentan-2-one · 108-10-1
- CAS No.
- 108-10-1
- Formula
- C6H12O
- Molar mass
- 100.16 g/mol
- PubChem CID
- 7909
Flammable
Toxic
Harmful / Irritant
Health hazard
Summary
methyl isobutyl ketone (C6H12O), CAS 108-10-1. Common in labs and industry. Read on for hazards, storage, PPE and mixing rules.
Background
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Physical properties
No experimental physical properties indexed yet. Try PubChem for the raw record.
Hazards
Ignites easily when exposed to a flame or spark.
May be fatal even in small doses.
May cause skin, eye or respiratory irritation.
Serious long-term health effects (CMR, respiratory sensitizer).
Hazard statements
- H225: Highly Flammable liquid and vapor [Danger Flammable liquids]
- H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H332: Harmful if inhaled [Warning Acute toxicity, inhalation]
- H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure
- H351: Suspected of causing cancer [Warning Carcinogenicity]
- H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure
- H350: May cause cancer [Danger Carcinogenicity]
- H320: Causes eye irritation [Warning Serious eye damage/eye irritation]
- H331: Toxic if inhaled [Danger Acute toxicity, inhalation]
- H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
- H303: May be harmful if swallowed [Warning Acute toxicity, oral]
- H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]
- H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]
Storage
Keep at room temperature, below 30 °C, out of direct heat.
Store somewhere well-ventilated and away from any ignition source.
Metal drums or tinted glass, tightly sealed.
Strong acids, strong bases and powerful oxidizers.
Personal protective equipment
Nitrile or butyl, at least 0.4 mm thick.
Safety goggles with side shields.
A2 organic-vapor cartridge if the room isn't well ventilated.
Occupational exposure limits (HSE)
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EU harmonised classification (ECHA C&L)
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Transport
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FDA recalls & enforcement
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Compatibilities
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Open comparator with methyl isobutyl ketonePractical safety notes
- Flammable. Keep away from open flames, hot surfaces and sparks. Ground containers when transferring.
- Acute toxicity. Work under a fume hood, restrict access, keep a specific antidote plan available.
- Irritant / harmful. Ventilate the workspace and avoid skin contact.
- Serious health hazard (carcinogen, mutagen, reprotoxic, respiratory sensitizer). Substitute if possible; otherwise closed systems and medical surveillance.
Derived from the GHS classification shown above. These notes are generic guidance and do not replace the manufacturer's SDS or your local risk assessment.
FAQ
Is methyl isobutyl ketone flammable?+
Yes. methyl isobutyl ketone (CAS 108-10-1) carries the GHS02 flame pictogram. Keep it away from ignition sources, use non-sparking tools, and ground metal containers when transferring liquid.
What PPE should I wear when handling methyl isobutyl ketone?+
Safety glasses with side shields and nitrile gloves are the baseline. Work inside a fume hood or use a suitable respirator. Check SDS section 8 for material-specific breakthrough times.
How should methyl isobutyl ketone be stored?+
Store methyl isobutyl ketone (CAS 108-10-1) in tightly closed original containers, in a cool, dry, well-ventilated area away from incompatible materials. Use a flammable-liquid cabinet and keep away from oxidizers and heat.
Is methyl isobutyl ketone dangerous for the environment?+
No specific environmental pictogram (GHS09) is listed in our records for methyl isobutyl ketone, but any chemical waste should be handled through your site's hazardous-waste procedure, not poured down the drain.
Where can I find the official Safety Data Sheet for methyl isobutyl ketone?+
Official, up-to-date SDS documents are published by each manufacturer (Sigma-Aldrich, Merck, Thermo Fisher, VWR, Carl Roth, etc.) and by regulators such as ECHA and NIOSH. This page is an educational summary and does not replace the manufacturer's SDS.
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