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tert-Butyldimethylsilyl chloride

Also known as: Tert-Butyldimethylsilyl chloride · 18162-48-6 · tert-Butyldimethylchlorosilane · t-Butyldimethylchlorosilane

CAS No.
18162-48-6
Formula
C6H15ClSi
Molar mass
150.72 g/mol
PubChem CID
28928
GHS pictograms
GHS pictogram: FlammableFlammable
GHS pictogram: CorrosiveCorrosive
GHS pictogram: Harmful / IrritantHarmful / Irritant
GHS pictogram: Environmental hazardEnvironmental hazard
2D structure of tert-Butyldimethylsilyl chloride
2D structure · PubChem CID 28928

Summary

tert-Butyldimethylsilyl chloride (C6H15ClSi), CAS 18162-48-6. Common in labs and industry. Read on for hazards, storage, PPE and mixing rules.

Background

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Physical properties

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Hazards

GHS pictogram: Flammable
Flammable (GHS02)

Ignites easily when exposed to a flame or spark.

GHS pictogram: Corrosive
Corrosive (GHS05)

Attacks skin, eyes and materials.

GHS pictogram: Harmful / Irritant
Harmful / Irritant (GHS07)

May cause skin, eye or respiratory irritation.

GHS pictogram: Environmental hazard
Environmental hazard (GHS09)

Toxic to aquatic organisms.

Hazard statements

Storage

Temperature

Keep at room temperature, below 30 °C, out of direct heat.

Ventilation

Store somewhere well-ventilated and away from any ignition source.

Containers

Metal drums or tinted glass, tightly sealed.

Keep away from

Strong acids, strong bases and powerful oxidizers.

Personal protective equipment

Gloves

Nitrile or butyl, at least 0.4 mm thick.

Eye protection

Safety goggles with side shields.

Respirator

A2 organic-vapor cartridge if the room isn't well ventilated.

Occupational exposure limits (HSE)

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EU harmonised classification (ECHA C&L)

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Transport

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FDA recalls & enforcement

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Compatibilities

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Practical safety notes

  • Flammable. Keep away from open flames, hot surfaces and sparks. Ground containers when transferring.
  • Corrosive. Wear chemical goggles, faceshield and chemical-resistant gloves. Have an eyewash within reach.
  • Irritant / harmful. Ventilate the workspace and avoid skin contact.
  • Environmental hazard. Do not release to sewers or waterways; collect for hazardous waste disposal.

Derived from the GHS classification shown above. These notes are generic guidance and do not replace the manufacturer's SDS or your local risk assessment.

FAQ

Is tert-Butyldimethylsilyl chloride flammable?+

Yes. tert-Butyldimethylsilyl chloride (CAS 18162-48-6) carries the GHS02 flame pictogram. Keep it away from ignition sources, use non-sparking tools, and ground metal containers when transferring liquid.

What PPE should I wear when handling tert-Butyldimethylsilyl chloride?+

Chemical-splash goggles and a faceshield, chemical-resistant gloves (nitrile or butyl) and an apron are the minimum. Ventilation should be sufficient to keep vapours below the occupational exposure limit. Check SDS section 8 for material-specific breakthrough times.

How should tert-Butyldimethylsilyl chloride be stored?+

Store tert-Butyldimethylsilyl chloride (CAS 18162-48-6) in tightly closed original containers, in a cool, dry, well-ventilated area away from incompatible materials. Use a flammable-liquid cabinet and keep away from oxidizers and heat. Segregate acids from bases and keep away from metals that can be attacked.

Is tert-Butyldimethylsilyl chloride dangerous for the environment?+

Yes. tert-Butyldimethylsilyl chloride carries the GHS09 environment pictogram. Do not release to drains, soil or waterways; collect residues for hazardous-waste disposal in line with local regulations.

Where can I find the official Safety Data Sheet for tert-Butyldimethylsilyl chloride?+

Official, up-to-date SDS documents are published by each manufacturer (Sigma-Aldrich, Merck, Thermo Fisher, VWR, Carl Roth, etc.) and by regulators such as ECHA and NIOSH. This page is an educational summary and does not replace the manufacturer's SDS.

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